Endress+Hauser Proline Promass U 500 Coriolis Flowmeter
The Endress+Hauser Proline Promass U 500 is a single-use Coriolis flowmeter developed specifically for biopharmaceutical and life sciences applications. It is designed for processes where single-use technology, hygienic operation, measurement accuracy and contamination control are essential. The instrument addresses the industry's shift from traditional multi-use equipment toward single-use systems and continuous biopharmaceutical manufacturing.
Promass U 500 uses the Coriolis measuring principle to provide direct liquid mass flow measurement. In addition to mass flow, the system supports multivariable process measurement, providing valuable measurement information for biopharmaceutical production and process monitoring.
Single-Use Flowmeter for Biopharmaceutical Processes
A key feature of the Promass U 500 is its disposable flowmeter concept. The single-use measuring assembly can be replaced between production processes, helping reduce cleaning requirements and minimizing the risk of cross-contamination between batches.
The disposable component uses 1.4435 / 316L stainless steel measuring tubes and Makrolon Rx 1805 polycarbonate hose connection components. The system is designed for fully traceable cGMP compliance, supporting the strict quality requirements of pharmaceutical and biotechnology manufacturing.
One Sensor for Four Line Sizes
Promass U 500 is designed around a flexible single-use sensor concept. One sensor can accommodate four disposable line sizes from 1/8 to 1 inch, providing a wide turndown ratio while simplifying equipment selection and inventory management.
The disposable assembly uses an intuitive clamping mechanism that allows one-hand mounting, helping operators install or replace the single-use flowmeter efficiently during process setup.
High-Accuracy Coriolis Measurement
The Promass U 500 provides a maximum liquid mass flow measurement error of ±0.5%. Its measuring range extends from 0 to 75 kg/min, making it suitable for a wide range of laboratory, pilot-scale and production bioprocess applications.
The Coriolis measuring principle provides direct mass flow measurement and enables the flowmeter to deliver reliable process information without requiring conventional flow conditioning equipment.
Flexible Installation and Self-Draining Design
The disposable sensor is designed to support different installation orientations. The mounting angle can be selected to facilitate self-drainability or air bubble escape, which is particularly important in biopharmaceutical liquid processes.
This installation flexibility helps users adapt the Promass U 500 to different single-use process assemblies and skid configurations.
cGMP-Compliant Single-Use Technology
For pharmaceutical and biotechnology production, compliance and traceability are critical. Promass U 500 is designed for cGMP-compliant single-use applications, supporting the quality and documentation requirements associated with biopharmaceutical manufacturing.
Its disposable architecture can help simplify process changeovers while reducing the need for cleaning and sterilization procedures associated with conventional reusable flowmeters.
Remote Transmitter and Digital Communication
The Promass U 500 is available with a remote transmitter configuration and supports up to four I/O connections. Modern communication options include fieldbus technologies such as Modbus TCP and PROFINET, depending on the selected configuration.
The transmitter provides access to process and diagnostic information, helping integrate the flowmeter into modern biopharmaceutical automation and process control systems.
Process Temperature and Pressure
The Promass U 500 is designed for liquid process temperatures from 3 to 60 °C and a maximum process pressure of 6 bar (87 psi). These specifications make it particularly suitable for controlled-temperature biopharmaceutical liquid processes rather than high-temperature or high-pressure industrial applications.
Typical Applications
The Endress+Hauser Proline Promass U 500 is suitable for:
Biopharmaceutical manufacturing
Biotechnology processes
Life sciences applications
Single-use bioprocessing
Continuous biomanufacturing
Pharmaceutical liquid flow measurement
Cell culture processes
Media and buffer preparation
Single-use process skids
Pilot-scale bioprocessing
Biopharma production systems
Key Features
Single-use Coriolis flowmeter
Designed for biopharmaceutical applications
cGMP-compliant design
Liquid mass flow measurement accuracy up to ±0.5%
Measuring range 0–75 kg/min
Process temperature 3–60 °C
Maximum process pressure 6 bar
One sensor for four disposable line sizes
Line sizes from 1/8 to 1 inch
One-hand disposable mounting
Self-draining / air bubble escape installation
316L / 1.4435 stainless steel measuring tubes
Makrolon Rx 1805 polycarbonate hose connection
Remote transmitter option
Up to 4 I/Os
Modbus TCP and PROFINET communication options
Suitable for single-use life sciences processes
